2010 Penn State Football Schedule
| 2010 | Date | PF | Opponent | PA | Location | Notes |
| #18 | 09-04-2010 | 44 | Youngstown St. (OH) | 14 | University Park, PA | 12 p.m. BTN |
| #14 | 09-11-2010 | 3 | #1 Alabama | 24 | Tuscaloosa, AL | 7 p.m. ESPN |
| #20 | 09-18-2010 | 24 | Kent State | 0 | University Park, PA | 12 p.m. ESPN2 |
| #20 | 09-25-2010 | 22 | Temple (PA) | 13 | University Park, PA | 3:30 p.m. BTN |
| #20 | 10-02-2010 | 3 | #17 Iowa | 24 | Iowa City, IA | 8 p.m. ESPN |
| NR | 10-09-2010 | 13 | Illinois | 33 | University Park, PA | 12 p.m. ESPN |
| NR | 10-23-2010 | 33 | Minnesota | 21 | Minneapolis, MN | 12 p.m. ESPNU |
| NR | 10-30-2010 | 41 | Michigan | 31 | University Park, PA | 8 p.m. ESPN |
| NR | 11-06-2010 | 35 | Northwestern | 21 | University Park, PA | 3:30 p.m. ESPN |
| NR | 11-13-2010 | 14 | Ohio St. | 38 | Columbus, OH | 3:30 p.m. ESPN |
| NR | 11-20-2010 | 41 | Indiana | 24 | Landover, MD | 12 p.m. BTN |
| NR | 11-27-2010 | 22 | Michigan St. | 28 | University Park, PA | 12 p.m. ESPN/Senior Day |
| NR | 1-1-2011 | – | Florida | – | Tampa, FL | 11 a.m. Outback Bowl |
| | – | Season Totals | – | | |